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Thermotherapy Special Topic

Clinical Application - Internal Medicine

Clinical Application - Surgery

Animal Experimentation

Intraperitoneal Thermal Perfusion Treatment Machine
Control cancerous implantation metastasis and prevent and treat malignant effusion in body cavities
 
Clinical Applicability
　　A. Intraoperative and postoperative adjuvant treatment for malignant tumors in body cavities such as lung cancer, gastric cancer, intestinal cancer, ovarian cancer, and pancreatic cancer to prevent implantation metastasis.
　　B. Postoperative treatment for cancer cells, metastatic nodules, enlarged lymph nodes, and residual small foci that cannot be removed by surgery.
　　C. Malignant effusion in body cavities (thoracic cavity, abdominal cavity)
　　D. Treatment of diffuse metastatic tumors in the thoracic and abdominal cavities
　　E. Treatment of malignant mesothelioma in the thoracic and abdominal cavities
 
 
Treatment Principle
　　Using the principle of tumor hyperthermia, the external electromagnetic induction heating device of the thermal chemotherapy perfusion system continuously heats the treatment solution to the therapeutic temperature, which is then introduced into the patient's body cavity through a circulation pump, maintaining an effective therapeutic temperature for 60 minutes to fully utilize the thermal killing mechanism; it performs thermal cleaning on metastatic cancer cells widely implanted on the serosa, and based on the characteristics of metabolic disorders and genetic material damage of cancer cells after hyperthermia, chemotherapeutic drugs with thermal sensitization effects are added to stop cancer cell division, eliminate the lesions that cause malignant effusion, and allow for rapid repair of the biological membrane, achieving effective treatment of cancerous effusion.
 
Changes before and after a single intraperitoneal circulation thermal perfusion treatment for effusion
 
 
 
Yellow
Hemorrhagic
Chylous
 
 
 
     
Gelatinous
Excreted fibrous tissue
Excreted tumor nodules

 

Operation Simulation Process

 

Start:B-ultrasound positioning
 
Enter:Puncture - single route perfusion
 
Exit:Puncture or catheter placement - switch to circulation mode after draining the effusion - preset temperature - when the body temperature reaches the therapeutic temperature, add chemotherapeutic drugs - maintain constant temperature circulation perfusion for 60 minutes
 
Maintain an appropriate amount of residual fluid in the body cavity:Treatment End
 
Pathological Images
 
   
Pleural effusion in lung adenocarcinoma: a large number of cancer cells can be seen. After a single thoracic thermal perfusion,only scattered cancer cell clusters can be found in the pleural effusion, most of which have undergone apoptosis and degeneration.Tumor tissue biopsy: before treatment, the cancer cell clusters vary in size and shape, with deep staining. After thermal perfusion treatment, the cancer cell clusters disappear.
   
   
Six advantages of ideal practical value
 
 
 
 
 
Short treatment course
　　1., averaging 3 treatments, average hospitalization time of 10 daysSignificant efficacy
　　2., the effective rate of controlling cancerous effusion is significantly improvedLong-term effects are stable
　　3., prolonged remission period, significantly improved quality of life, and reduced recurrence rateNo sequelae
　　4., does not cause damage to physiological functions or adverse sequelaeToxic side effects
　　5., reduces the toxic side effects of chemotherapeutic drugs in body cavitiesNew methods
　　6., a good method to prevent and treat cancerous implantation metastasis and control malignant effusion in the abdominal cavity——"Clinical Application of Constant Temperature Circulation Thermal Perfusion Chemotherapy for the Prevention and Treatment of Body Cavity Metastatic Cancer"
Clinical Indications
 
▼
　Treatment of gastric cancer, ovarian cancer, lung cancer, breast cancer, mesothelioma, and metastatic tumors in the thoracic and abdominal cavities during and after surgery to prevent implantation metastasis.
Postoperative treatment for cancer cells, metastatic nodules, enlarged lymph nodes, and residual lesions that cannot be removed by surgery.
Malignant effusion in body cavities (thoracic cavity, abdominal cavity)
Treatment of diffuse metastatic tumors in the thoracic and abdominal cavities
Treatment of malignant mesothelioma in the thoracic and abdominal cavities
Contraindications
 
Patients with severe thoracic and abdominal adhesions
　Treatment of gastric cancer, ovarian cancer, lung cancer, breast cancer, mesothelioma, and metastatic tumors in the thoracic and abdominal cavities during and after surgery to prevent implantation metastasis.
Intestinal obstruction, liver cirrhosis with ascites
ECOG > 2, extremely poor physical condition, unable to tolerate thermal perfusion treatment
Patients with bleeding tendency diseases
Patients with inguinal hernia, patients with diaphragmatic hernia
Patients with poor compliance.
依从性差的患者