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2024.09.26

The National Cancer Center has just released: 2024 National Cancer Report

Recently, with the approval of the National Health Commission, the National Cancer Center released the 2022 burden of malignant tumors in China based on the latest data from tumor registration and follow-up monitoring on JNCC. The results released this time are jointly calculated by the National Cancer Center and the International Agency for Research on Cancer (IARC), consistent with the Chinese data published by IARC in GLOBOCAN 2022 and released simultaneously.

2025.04.29

Good Doctor. Hyperthermic Intraperitoneal Chemotherapy (HIPEC)丨Reprint 5: Focus on active treatment options for peritoneal surface malignancies. Research progress on cytoreductive surgery and HIPEC in Northern Europe.

Colorectal cancer with peritoneal metastasis remains a significant therapeutic challenge. While cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has been the mainstay of treatment, questions regarding the optimal HIPEC regimen persist. The PRODIGE7 trial challenged the efficacy of oxaliplatin-based HIPEC, leading to a greater focus on novel combination therapies. The ongoing EFFIPEC trial aims to refine HIPEC regimens by evaluating intensified chemotherapy regimens. This article provides an update on the interim analysis of this trial and highlights international collaborations, particularly with the HIPEC network of the Indian Society of Peritoneal Surface Malignancies (INDEPSO). Furthermore, potential new research initiatives in the Nordic countries regarding pseudomyxoma peritonei are introduced.

2025.04.29

Good Doctor. Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Alternative to Traditional HIPEC - Three and Four Cycles of HIPEC

Intraperitoneal hyperthermic chemotherapy (IPHC) has remained largely unchanged in the past 30 years. It is used to prevent peritoneal metastasis in patients with a high risk of disease progression in gastric or colorectal cancer, and more commonly to treat patients with peritoneal metastasis from ovarian, gastric, colorectal, and appendiceal cancers. After undergoing cytoreductive surgery, IPHC is used to help maintain a disease-free state in the peritoneal and pelvic cavities. From a theoretical perspective and analysis of IPHC failures, this treatment method has several shortcomings. First, perhaps the most serious criticism of IPHC is its insufficient "dwell time" in the peritoneal and pelvic cavities. The chemotherapy solution is maintained at 41-43 degrees Celsius using a hyperthermia pump for only 90 minutes. This limited drug exposure time is even more problematic for residual micrometastases, as high intraperitoneal concentrations of most chemotherapeutic drugs are only maintained for 30-60 minutes. High-molecular-weight drugs like paclitaxel diffuse more slowly from the peritoneal cavity. Low-molecular-weight drugs like cisplatin no longer maintain high concentrations in the peritoneal cavity after only 20 minutes. My conclusion is that increasing the dwell time of chemotherapeutic drugs in the peritoneal cavity is the primary condition for achieving greater efficacy of IPHC.

2025.04.29

Good Doctor. Hot Infusion | Reprint 3: List of Upcoming Events, including the 9th Indian Society of Peritoneal Surface Oncology (INDEPSO)

9th Annual INDEPSO-ISPSM Peritoneal Malignancy Advances Symposium

2025.04.29

Good Doctor. Hot Infusion | Reprint 2: Progress and achievements of PSOGI/PSM certified centers of excellence. Milan Cancer Institute's contribution to peritoneal oncology: Past, present and future

In the mid-1990s, the Italian National Cancer Institute (Fondazione IRCCS Istituto Nazionale dei Tumori) in Milan established a Peritoneal Surface Malignancies (PSM) program, becoming one of the pioneering centers for peritoneal tumors in Europe. After completing surgical training in Washington, D.C. with Dr. Paul Sugarbaker, Marcello Deraco assembled a specialized team to treat peritoneal malignancies, which were then considered largely incurable. At the time, systemic chemotherapy was considered to have limited efficacy against peritoneal malignancies, and surgery was viewed as purely palliative.

2025.04.29

Good Doctor. Hot Infusion | Reprint 1: Clinical or laboratory research progress -- Small bowel transplantation for pseudomyxoma peritonei

Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterized by mucinous ascites, peritoneal implants, and the formation of omental cakes. The vast majority of PMP originates from perforation of appendiceal mucinous tumors, while a minority originates from other organs such as the ovaries, umbilical cord, colon, and pancreas. Perforation of mucinous tumors leads to the shedding of mucin and mucin-producing epithelial cells into the peritoneal cavity. Through redistribution, it spreads sequentially to the right paracolic gutter, right subphrenic space, left subphrenic space (including the spleen), greater omentum, and pelvic floor (including the ovaries and uterus in females) [Carr NJ et al., Am J Surg Pathol. 2016]. PMP usually progresses slowly and rarely metastasizes to lymph nodes or distant sites.

2025.04.07

Forwarding: Quality Control Considerations for Intraperitoneal Hyperthermic Chemotherapy: How to Avoid Instability in Perfusion

For peritoneal carcinomatosis or malignant ascites, hyperthermic intraperitoneal chemotherapy (HIPEC) is the standard approach. Of course, some patients undergo cytoreductive surgery (CRS) before HIPEC to reduce tumor burden and even achieve radical resection of organs affected by the tumor for better efficacy. Here, we focus on infusion instability.

2025.04.07

Repost: CRS+HIPEC can still be performed and benefit patients even if there is extraperitoneal tumor involvement.

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